Flavonol dimers from callus cultures of Dysosma versipellis and their in vitro neuraminidase inhibitory activities

Abstract

A chemical investigation of callus cultures of Dysosma versipellis led to the isolation of five new flavonol dimers, dysoverines A-E (1-5), together with 12 known compounds (6-17). The structures of new compounds were determined by the extensive spectroscopic data analyses. The biosynthetic pathway of the new compounds was proposed to involve O-methylation, prenylation, and Diels-Alder cycloaddition, which successively occurred in cultured plant cells. Compounds 1-17 exhibited in vitro neuraminidase inhibitory activities with the IC50 values of 31.0-93.9μM.

Keywords: Callus culture; Dysosma versipellis; Flavonol dimer; Neuraminidase inhibitory activity.