Biomimetic composite microspheres of collagen/chitosan/nano-hydroxyapatite: In-situ synthesis and characterization

Mater Sci Eng C Mater Biol Appl. 2016 Jan 1:58:610-3. doi: 10.1016/j.msec.2015.09.021. Epub 2015 Sep 7.

Abstract

The collagen/chitosan/hydroxyapatite (COL/CS/HA) composite microspheres with a good spherical form and a high dispersity were successfully obtained using an in-situ synthesis method. The FT-IR and XRD results revealed that the inorganic phase in the microspheres was crystalline HA containing carbonate ions. The morphology of the composite microspheres was dependent on the HA content, and a more desirable morphology was achieved when 20 wt.% HA was contained. The composite microspheres exhibited a narrow particle distribution, most of which ranged from 5 to 10 μm. In addition, the needle-like HA nano-particles were uniformly distributed in the composite microspheres, and their crystallinity and crystal size decreased with the HA content.

Keywords: Biomaterials; Composite; In-situ synthesis; Microspheres; Microstructure.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemical synthesis*
  • Biocompatible Materials / chemistry*
  • Chitosan / chemistry*
  • Collagen / chemistry*
  • Durapatite / chemistry*
  • Microspheres*
  • Particle Size

Substances

  • Biocompatible Materials
  • Collagen
  • Chitosan
  • Durapatite