A tale of the unexpected: Amyloidoma associated with intracerebral lymphoplasmacytic lymphoma

J Neurol Sci. 2015 Dec 15;359(1-2):404-8. doi: 10.1016/j.jns.2015.09.372. Epub 2015 Oct 23.

Abstract

Amyloidoma is a rare cause for intracranial space-occupying lesions diagnosed on brain imaging. Histology of excised tissue usually reveals the presence of a discrete, λ-light chain secreting plasmacytoma adjacent to an amyloid mass comprising aggregated monoclonal immunoglobulin light chains. We described a patient with intracerebral amyloidoma associated with a localised lymphoplasmacytic lymphoma and no systemic paraproteinaemia, tumour or amyloid deposits.

Keywords: Amyloidoma; Amyloidosis; Immunoglobulin light chain; Lymphoplasmacytic lymphoma; Plasmacytoma.

Publication types

  • Case Reports

MeSH terms

  • Amyloidosis / diagnosis
  • Amyloidosis / etiology*
  • Amyloidosis / surgery
  • Craniotomy
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Middle Aged
  • Tomography Scanners, X-Ray Computed
  • Waldenstrom Macroglobulinemia / complications*
  • Waldenstrom Macroglobulinemia / surgery