Primary Immunodeficiency Masquerading as Allergic Disease

Sanny K Chan; Erwin W Gelfand

doi:10.1016/j.iac.2015.07.008

Primary Immunodeficiency Masquerading as Allergic Disease

Immunol Allergy Clin North Am. 2015 Nov;35(4):767-78. doi: 10.1016/j.iac.2015.07.008. Epub 2015 Sep 4.

Authors

Sanny K Chan¹, Erwin W Gelfand²

Affiliations

¹ Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA. Electronic address: chans@njhealth.org.
² Division of Allergy and Immunology, Department of Pediatrics, National Jewish Health, 1400 Jackson Street, Denver, CO 80206, USA.

PMID: 26454318
DOI: 10.1016/j.iac.2015.07.008

Abstract

Primary immune deficiencies (PIDs) are an uncommon heterogeneous group of diseases that result from fundamental defects in the proteins and cells that enable specific immune responses. Common allergic reactions (eczema, allergic rhinitis, asthma, and food allergies) are exaggerated immune responses that may be manifestations of an underlying PID. Early diagnosis and treatment has significant bearing on outcome. Immune suppression with systemic corticosteroids in these immune compromised individuals can lead to life threatening dissemination of infections.

Keywords: Allergic disease; Corticosteroids; Eczema; Elevated IgE; Primary immune deficiency.

Publication types

Review

MeSH terms

Diagnosis, Differential
Disease Management
Eczema / complications
Eczema / diagnosis
Eczema / immunology
Humans
Hypersensitivity / complications*
Hypersensitivity / diagnosis
Hypersensitivity / immunology*
Immunoglobulin E / immunology
Immunologic Deficiency Syndromes / complications*
Immunologic Deficiency Syndromes / diagnosis*
Immunologic Deficiency Syndromes / etiology
Immunologic Deficiency Syndromes / therapy
Infant
Infant, Newborn

Substances

Immunoglobulin E