Sugar? No Thank You, Just a Deep Breath of Oxygen for Cancer Stem Cells

Andrea Viale; Giulio F Draetta

doi:10.1016/j.cmet.2015.09.020

Sugar? No Thank You, Just a Deep Breath of Oxygen for Cancer Stem Cells

Cell Metab. 2015 Oct 6;22(4):543-5. doi: 10.1016/j.cmet.2015.09.020.

Authors

Andrea Viale¹, Giulio F Draetta²

Affiliations

¹ Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Electronic address: aviale@mdanderson.org.
² Department of Genomic Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Molecular and Cellular Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

PMID: 26445511
DOI: 10.1016/j.cmet.2015.09.020

Abstract

Tumors are metabolically heterogeneous, and subpopulations of tumorigenic cells have been recently described to rely more on mitochondrial respiration than glycolysis for energy production. In this issue, Sancho et al. (2015) demonstrate that MYC is a master switch regulating metabolic programs in different subpopulations of pancreatic tumor cells.

Publication types

Comment

MeSH terms

Animals
Humans
Proto-Oncogene Proteins c-myc / metabolism*
Transcription Factors / metabolism*

Substances

Proto-Oncogene Proteins c-myc
Transcription Factors