Abstract
The first water soluble maleimide bearing NIR BF2-azadipyrromethene (NIR-AZA) fluorochrome has been synthesised which is capable of rapid thiol conjugations in water with peptides such as glutathione, the cell penetrating peptide (CPP) C(β-A)SKKKKTKV-NH2 and a thiol substituted cRGD. NIR fluorescence imaging showed rapid cellular delivery of the CPP conjugate and effective in vivo tumour localization for the cRGD conjugate.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aza Compounds / chemical synthesis*
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Aza Compounds / chemistry
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Aza Compounds / pharmacokinetics
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Fluorescence
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Fluorescent Dyes / chemical synthesis*
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Fluorescent Dyes / chemistry
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Fluorescent Dyes / pharmacokinetics
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Glutathione / chemistry
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Glutathione / pharmacokinetics
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HeLa Cells
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Humans
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Infrared Rays*
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Maleimides / chemistry*
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Maleimides / pharmacokinetics
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Mice
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Molecular Structure
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Neoplasms, Experimental / metabolism
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Peptides, Cyclic / chemistry
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Peptides, Cyclic / pharmacokinetics
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Porphobilinogen / analogs & derivatives*
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Porphobilinogen / chemistry
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Porphobilinogen / pharmacokinetics
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Sulfhydryl Compounds / chemistry
Substances
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Aza Compounds
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Fluorescent Dyes
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Maleimides
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Peptides, Cyclic
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Sulfhydryl Compounds
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cyclic arginine-glycine-aspartic acid peptide
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dipyrromethene
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maleimide
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Porphobilinogen
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Glutathione