Substance use and mental diagnoses among adults with and without type 2 diabetes: Results from electronic health records data

Drug Alcohol Depend. 2015 Nov 1:156:162-169. doi: 10.1016/j.drugalcdep.2015.09.003. Epub 2015 Sep 12.

Abstract

Background: Comorbid diabetes and substance use diagnoses (SUD) represent a hazardous combination, both in terms of healthcare cost and morbidity. To date, there is limited information about the association of SUD and related mental disorders with type 2 diabetes mellitus (T2DM).

Methods: We examined the associations between T2DM and multiple psychiatric diagnosis categories, with a focus on SUD and related psychiatric comorbidities among adults with T2DM. We analyzed electronic health record (EHR) data on 170,853 unique adults aged ≥18 years from the EHR warehouse of a large academic healthcare system. Logistic regression analyses were conducted to estimate the strength of an association for comorbidities.

Results: Overall, 9% of adults (n=16,243) had T2DM. Blacks, Hispanics, Asians, and Native Americans had greater odds of having T2DM than whites. All 10 psychiatric diagnosis categories were more prevalent among adults with T2DM than among those without T2DM. Prevalent diagnoses among adults with T2MD were mood (21.22%), SUD (17.02%: tobacco 13.25%, alcohol 4.00%, drugs 4.22%), and anxiety diagnoses (13.98%). Among adults with T2DM, SUD was positively associated with mood, anxiety, personality, somatic, and schizophrenia diagnoses.

Conclusions: We examined a large diverse sample of individuals and found clinical evidence of SUD and psychiatric comorbidities among adults with T2DM. These results highlight the need to identify feasible collaborative care models for adults with T2DM and SUD related psychiatric comorbidities, particularly in primary care settings, that will improve behavioral health and reduce health risk.

Keywords: Anxiety disorder; Comorbidity; Diabetes mellitus; Electronic health records; Mood disorder; Substance use disorder.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Aged
  • Aged, 80 and over
  • Anxiety Disorders / complications
  • Anxiety Disorders / epidemiology
  • Anxiety Disorders / psychology
  • Diabetes Mellitus, Type 2 / complications*
  • Diabetes Mellitus, Type 2 / epidemiology
  • Diabetes Mellitus, Type 2 / psychology*
  • Diagnosis, Dual (Psychiatry)
  • Electronic Health Records
  • Ethnicity
  • Female
  • Humans
  • International Classification of Diseases
  • Male
  • Mental Disorders / complications*
  • Mental Disorders / epidemiology
  • Mental Disorders / psychology*
  • Middle Aged
  • Mood Disorders / complications
  • Mood Disorders / epidemiology
  • Mood Disorders / psychology
  • Personality Disorders / complications
  • Personality Disorders / epidemiology
  • Personality Disorders / psychology
  • Prevalence
  • Schizophrenia / complications
  • Schizophrenia / epidemiology
  • Substance-Related Disorders / complications*
  • Substance-Related Disorders / epidemiology
  • Substance-Related Disorders / psychology*
  • Young Adult