Interfacial thiol-isocyanate reactions for functional nanocarriers: a facile route towards tunable morphologies and hydrophilic payload encapsulation

Chem Commun (Camb). 2015 Nov 11;51(87):15858-15861. doi: 10.1039/c5cc05258k.

Abstract

Functional nanocarriers were synthesized using an in situ inverse miniemulsion polymerization employing thiol-isocyanate reactions at the droplet interface to encapsulate hydrophilic payloads. The morphology of the nanocarriers is conveniently tunable by varying the reaction conditions and the dispersions are easily transferable to the aqueous phase.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibiotics, Antineoplastic / chemistry
  • Doxorubicin / chemistry
  • Drug Delivery Systems*
  • Emulsions
  • HeLa Cells
  • Humans
  • Hydrophobic and Hydrophilic Interactions
  • Isocyanates / chemistry*
  • Nanoparticles / chemistry*
  • Particle Size
  • Potassium Chloride / chemistry
  • Sulfhydryl Compounds / chemistry*
  • Toluene 2,4-Diisocyanate / chemistry
  • Urethane / chemical synthesis

Substances

  • Antibiotics, Antineoplastic
  • Emulsions
  • Isocyanates
  • Sulfhydryl Compounds
  • Toluene 2,4-Diisocyanate
  • Urethane
  • Potassium Chloride
  • Doxorubicin