The in situ synthesis of Ag/amino acid biopolymer hydrogels as mouldable wound dressings

Chem Commun (Camb). 2015 Nov 11;51(87):15862-5. doi: 10.1039/c5cc05195a.

Abstract

This manuscript introduces a one-pot fabrication procedure for the preparation of supramolecular hybrid hydrogels from low-cost commercially available natural products through a "green" strategy. In particular, the hybrid hydrogels, which are developed with Fmoc-Glu-OMe, silver nanoparticles and chitosan, exhibit outstanding antibacterial properties and can be regarded as excellent mouldable wound healing biomaterials.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Anti-Bacterial Agents / chemical synthesis
  • Anti-Bacterial Agents / pharmacology*
  • Bandages, Hydrocolloid*
  • Chitosan / chemistry
  • Escherichia coli / drug effects
  • Fluorenes / chemistry*
  • Glutamic Acid / analogs & derivatives*
  • Glutamic Acid / chemistry
  • Green Chemistry Technology
  • Hydrogels
  • Male
  • Metal Nanoparticles / chemistry
  • Nanocomposites / chemistry
  • Particle Size
  • Rats
  • Rats, Sprague-Dawley
  • Silver Nitrate / chemistry

Substances

  • Anti-Bacterial Agents
  • Fluorenes
  • Fmoc-glutamic acid methyl ester
  • Hydrogels
  • Glutamic Acid
  • Chitosan
  • Silver Nitrate