Paradoxical enlargement of intracranial tuberculomas during treatment of tuberculous meningitis: report of a case

Taiwan Yi Xue Hui Za Zhi. 1989 Oct;88(10):1067-70.

Abstract

We report a case of a 32-year-old man who showed paradoxical enlargement of pathologically verified intracranial tuberculomas during a course of adequate antituberculous chemotherapy. Serial computed tomographic scans of the brain disclosed this uncommon phenomenon. Total excision of the lesions with concomitant four-combined antituberculous therapy proved successful. Although the mechanism of this paradoxical phenomenon is not well understood, a defective local tissue immune response with gradually increasing maturity of the lesions during antituberculous therapy, which results in poor penetration of these drugs into the lesions, might be a possible explanation.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antitubercular Agents / adverse effects
  • Antitubercular Agents / therapeutic use*
  • Brain Diseases / drug therapy
  • Brain Diseases / pathology
  • Humans
  • Male
  • Tuberculoma / drug therapy
  • Tuberculoma / pathology
  • Tuberculosis, Meningeal / drug therapy*

Substances

  • Antitubercular Agents