Oxygen transport and demand were examined in 71 patients with myocardial infarction within the first 5 weeks of the disease. The volume of blood-transported oxygen was shown to be determined mainly by the blood circulatory minute volume. Lower arterial blood oxygen is an additional factor of diminished oxygen transport in hypodynamic central hemodynamics. Within the first 5-10 days of myocardial infarction, there was a progressive reduction in oxygen transport, but by days of 28-35, there was its gradual increase. These changes are the most prominent in patients with a hyperdynamic type and negligible in those with a hypodynamic type within the first 24 hours of myocardial infarction. The important of oxygen transport decrease compensation is its increased tissue extraction from arterial blood, thereby providing the stable oxygen demand in the wide range of its supply fluctuations.