A Dispersion-Dominated Chromogenic Strategy for Colorimetric Sensing of Glutathione at the Nanomolar Level Using Gold Nanoparticles

Yunlei Xianyu; Yangzhouyun Xie; Nuoxin Wang; Zhuo Wang; Xingyu Jiang

doi:10.1002/smll.201500903

A Dispersion-Dominated Chromogenic Strategy for Colorimetric Sensing of Glutathione at the Nanomolar Level Using Gold Nanoparticles

Small. 2015 Nov 4;11(41):5510-4. doi: 10.1002/smll.201500903. Epub 2015 Aug 27.

Authors

Yunlei Xianyu^{1

2}, Yangzhouyun Xie^{1

2}, Nuoxin Wang¹, Zhuo Wang¹, Xingyu Jiang¹

Affiliations

¹ Beijing Engineering Research Center for BioNanotechnology & Key Lab for Biological Effects of Nanomaterials and Nanosafety, National Center for NanoScience and Technology, Beijing, 100190, P. R. China.
² University of Chinese Academy of Sciences, Beijing, 100049, P. R. China.

PMID: 26313890
DOI: 10.1002/smll.201500903

Abstract

A dispersion-dominated chromogenic strategy for glutathione sensing is developed. Glutathione prevents the aggregation of arginine-modified gold nanoparticles via mercury-thiol interaction, which allows for glutathione sensing at the nanomolar level (10.9 × 10(-9) m) with facile operation and naked-eye readout.

Keywords: cancer cells; colorimetric sensors; glutathione; gold nanoparticles; mercury.

Publication types

Evaluation Study
Research Support, Non-U.S. Gov't

MeSH terms

Chromogenic Compounds / chemical synthesis
Colorimetry / instrumentation*
Equipment Design
Equipment Failure Analysis
Glutathione / analysis*
Glutathione / chemistry
Gold / chemistry*
Mercury / chemistry*
Metal Nanoparticles / chemistry*
Metal Nanoparticles / ultrastructure
Microchemistry / instrumentation
Reproducibility of Results
Sensitivity and Specificity
Sulfhydryl Compounds / chemistry*

Substances

Chromogenic Compounds
Sulfhydryl Compounds
Gold
Mercury
Glutathione