Randomized Controlled Trial to Determine the Impact of Probiotic Administration on Colonization With Multidrug-Resistant Organisms in Critically Ill Patients

Infect Control Hosp Epidemiol. 2015 Dec;36(12):1451-4. doi: 10.1017/ice.2015.195. Epub 2015 Aug 27.

Abstract

This was a randomized controlled pilot study of Lactobacillus rhamnosus GG versus standard of care to prevent gastrointestinal multidrug-resistant organism colonization in intensive care unit patients. Among 70 subjects, there were no significant differences in acquisition or loss of any multidrug-resistant organisms (P>.05) and no probiotic-associated adverse events.

Publication types

  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cross Infection / prevention & control*
  • Drug Resistance, Multiple / drug effects*
  • Female
  • Gastrointestinal Diseases / drug therapy
  • Gastrointestinal Diseases / prevention & control*
  • Hospitals, University
  • Humans
  • Intensive Care Units
  • Lacticaseibacillus rhamnosus
  • Male
  • Middle Aged
  • Missouri
  • Pilot Projects
  • Probiotics / administration & dosage*
  • Standard of Care
  • Treatment Outcome
  • Young Adult