Several Conventional Risk Markers Suggesting Presence of Albuminuria Are Weak Among Rural Africans With Hypertension

J Clin Hypertens (Greenwich). 2016 Jan;18(1):27-30. doi: 10.1111/jch.12662. Epub 2015 Aug 26.

Abstract

The objective of this cross-sectional study was to investigate risk markers indicating the presence of albuminuria in patients with hypertension in rural sub-Saharan Africa (SSA). Urine albumin-creatinine ratio, glycated hemoglobin (HbA1c ), blood pressure, anthropometry, and other patient characteristics including medications were assessed. We identified 160 patients with hypertension, of whom 68 (42.5%) were co-diagnosed with diabetes mellitus (DM). Among the included participants, 57 (35.6%) had albuminuria (microalbuminuria [n=43] and macroalbuminuria [n=14]). A backward multivariate logistic regression model identified age (per 10-year increment) (odds ratio [OR], 1.42; 95% confidence interval [CI], 1.03-1.95), HbA1c >53 compared with <48 mmol/mol (OR, 3.81; 95% CI, 1.74-8.35), and treatment with dihydropyridine calcium channel blockers (OR, 2.59; 95% CI, 1.09-6.16) as the variables significantly associated with albuminuria. Only dysregulated DM and age were the conventional risk markers that seemed to suggest albuminuria among patients with hypertension in rural SSA.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Albuminuria / blood
  • Albuminuria / diagnosis
  • Albuminuria / physiopathology
  • Albuminuria / urine*
  • Biomarkers / blood
  • Biomarkers / urine
  • Blood Pressure / physiology
  • Cross-Sectional Studies
  • Female
  • Glycated Hemoglobin / analysis
  • Humans
  • Hypertension / blood
  • Hypertension / physiopathology
  • Hypertension / urine*
  • Male
  • Middle Aged
  • Risk
  • Rural Population
  • Zambia

Substances

  • Biomarkers
  • Glycated Hemoglobin A