Enzyme-Responsive Nanoparticles for Targeted Accumulation and Prolonged Retention in Heart Tissue after Myocardial Infarction

Adv Mater. 2015 Oct 7;27(37):5547-52. doi: 10.1002/adma.201502003. Epub 2015 Aug 25.

Abstract

A method for targeting to and retaining intravenously injected nanoparticles at the site of acute myocardial infarction in a rat model is described. Enzyme-responsive peptide-polymer amphiphiles are assembled as spherical micellar nanoparticles, and undergo a morphological transition from spherical-shaped, discrete materials to network-like assemblies when acted upon by matrix metalloproteinases (MMP-2 and MMP-9), which are up-regulated in heart tissue post-myocardial infarction.

Keywords: MMPs; enzyme-responsive; intravenous injection; myocardial infarction; nanoparticles.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Disease Models, Animal
  • Drug Carriers / chemistry*
  • Drug Delivery Systems / methods
  • Dynamic Light Scattering
  • Fluorescence
  • Heart / drug effects*
  • Hydrophobic and Hydrophilic Interactions
  • Injections, Intravenous
  • Matrix Metalloproteinase 2 / metabolism*
  • Matrix Metalloproteinase 9 / metabolism*
  • Micelles
  • Myocardial Infarction / drug therapy*
  • Myocardial Infarction / enzymology
  • Myocardium / enzymology
  • Nanoparticles / chemistry*
  • Polymers / chemistry
  • Rats
  • Time Factors

Substances

  • Drug Carriers
  • Micelles
  • Polymers
  • Matrix Metalloproteinase 2
  • Mmp2 protein, rat
  • Matrix Metalloproteinase 9
  • Mmp9 protein, rat