Evaluation of the Meritas® BNP Test for Point-of-Care Testing

Clin Lab. 2015;61(7):727-30. doi: 10.7754/clin.lab.2014.140815.

Abstract

Background: BNP and NT-proBNP are widely used as rule-out tests for heart failure (HF) and they are frequently requested by primary care doctors. A point-of-care (POC) test would reduce the time to diagnosis for patients with suspected HF. The aim of the study was to evaluate a POC BNP test.

Methods: Plasma BNP results obtained with the Meritas® POC instrument (n = 82) were compared with the corresponding plasma BNP results analyzed on an Advia Centaur analyzer (Siemens Healthcare, Erlangen, Germany).

Results: The two methods showed concordant results with a Passing-Bablok correlation between the two methods: BNP(Meritas) = 1.00 x BNP(Siemens) + 1.09; r = 0.9773.

Conclusions: The study show that the Meritas® BNP assay could be used in primary care permitting rapid BNP testing to rule out heart failure.

Publication types

  • Comparative Study
  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / blood
  • Equipment Design
  • Heart Failure / blood
  • Heart Failure / diagnosis*
  • Humans
  • Immunoassay* / instrumentation
  • Natriuretic Peptide, Brain / blood*
  • Peptide Fragments / blood*
  • Point-of-Care Systems*
  • Predictive Value of Tests
  • Time Factors

Substances

  • Biomarkers
  • Peptide Fragments
  • pro-brain natriuretic peptide (1-76)
  • Natriuretic Peptide, Brain