Two site genetic incorporation of varying length polyethylene glycol into the backbone of one peptide

Chem Commun (Camb). 2015 Oct 1;51(76):14385-8. doi: 10.1039/c5cc04486c. Epub 2015 Aug 14.

Abstract

Polyethylene glycol (PEG) of different lengths was genetically incorporated into the backbone of a polypeptide using stop-anticodon and frameshift anticodon-containing tRNAs, which were acylated with PEG-containing amino acids.

MeSH terms

  • Acylation
  • Amino Acid Sequence
  • Amino Acids / chemistry
  • Amino Acids / genetics*
  • Anticodon
  • Molecular Sequence Data
  • Peptides / chemistry*
  • Peptides / genetics*
  • Polyethylene Glycols / chemistry*
  • Protein Biosynthesis
  • RNA, Transfer / chemistry
  • RNA, Transfer / genetics*

Substances

  • Amino Acids
  • Anticodon
  • Peptides
  • Polyethylene Glycols
  • RNA, Transfer