Abstract
Faithful chromosome segregation is critical in preventing genome loss or damage during cell division. Failure to properly disentangle catenated sister chromatids can lead to the formation of bulky or ultrafine anaphase bridges, and ultimately genome instability. In this review we present an overview of the current state of knowledge of how sister chromatid decatenation is carried out, with particular focus on the role of TOP2A and TOPBP1 in this process.
Keywords:
anaphase bridges, mitosis, sister chromatid decatenation, TOP2A, TOPBP1, UFB.
Publication types
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Anaphase / genetics
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Anaphase / physiology
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Animals
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Antigens, Neoplasm / genetics
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Antigens, Neoplasm / metabolism
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Carrier Proteins / genetics
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Carrier Proteins / metabolism
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Cell Cycle / genetics
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Cell Cycle / physiology
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Chromatids / metabolism*
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Chromosome Segregation / genetics
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Chromosome Segregation / physiology
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DNA Topoisomerases, Type II / genetics
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DNA Topoisomerases, Type II / metabolism
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / metabolism
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Humans
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Mitosis / genetics
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Mitosis / physiology
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Nuclear Proteins / genetics
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Nuclear Proteins / metabolism
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Poly-ADP-Ribose Binding Proteins
Substances
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Antigens, Neoplasm
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Carrier Proteins
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DNA-Binding Proteins
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Nuclear Proteins
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Poly-ADP-Ribose Binding Proteins
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TOPBP1 protein, human
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DNA Topoisomerases, Type II
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TOP2A protein, human