Design, Synthesis and Biological Evaluation of β-Carboline Dimers Based on the Structure of Neokauluamine

Jaruwan Chatwichien; Subhasree Basu; Maureen E Murphy; Mark T Hamann; Jeffrey D Winkler

doi:10.1016/j.tetlet.2015.01.142

Design, Synthesis and Biological Evaluation of β-Carboline Dimers Based on the Structure of Neokauluamine

Tetrahedron Lett. 2015 Jun 3;56(23):3515-3517. doi: 10.1016/j.tetlet.2015.01.142.

Authors

Jaruwan Chatwichien¹, Subhasree Basu², Maureen E Murphy², Mark T Hamann³, Jeffrey D Winkler¹

Affiliations

¹ Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104.
² The Wistar Institute, Philadelphia, PA 19104.
³ Department of BioMolecular Sciences, University of Mississippi, University, MS 38677.

Abstract

The design, synthesis and biological evaluation (anticancer and antimalarial activity) of bis-β-carbolines, based on the structure of the naturally occurring alkaloid neokauluamine, is described.

Keywords: Manzamine alkaloids; structure-activity relationships (SAR); β-carboline heterocycle.

Abstract

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