Different switching patterns of β-thalassaemic mutations at the proximal and distal CACCC box of the human HBB (β-globin) gene

Br J Haematol. 2016 Jun;173(5):794-7. doi: 10.1111/bjh.13636. Epub 2015 Aug 7.
No abstract available

Keywords: animal model; globin genes; haemoglobin regulation; β-thalassaemia.

Publication types

  • Letter

MeSH terms

  • Animals
  • Gene Silencing
  • Humans
  • Mice
  • Mice, Transgenic
  • Mutation*
  • Nucleotide Motifs
  • Promoter Regions, Genetic / genetics*
  • Protein Binding
  • Transcription Factors / genetics
  • Transcription Factors / metabolism
  • Transcriptional Activation
  • beta-Globins / genetics*
  • beta-Thalassemia / genetics*

Substances

  • Transcription Factors
  • beta-Globins