[Severe Caffeine Intentional Intoxication and Delayed Elimination: a Case Report]

Mélody Barreau; Bérengère Lambert; Julien Tobarias; Dominique Lambert; Julien Dupouey; Olivier Blin; Romain Guilhaumou

doi:10.2515/therapie/2015045

[Severe Caffeine Intentional Intoxication and Delayed Elimination: a Case Report]

Therapie. 2015 Nov-Dec;70(6):551-3. doi: 10.2515/therapie/2015045. Epub 2015 Aug 3.

[Article in French]

Authors

Mélody Barreau¹, Bérengère Lambert¹, Julien Tobarias², Dominique Lambert², Julien Dupouey¹, Olivier Blin¹, Romain Guilhaumou¹

Affiliations

¹ Service de Pharmacologie Clinique, CHU Timone, AP-HM, Marseille, France.
² Service de Réanimation Urgences et Médicale, CHU Timone, AP-HM, Marseille, France.

PMID: 26238128
DOI: 10.2515/therapie/2015045

Abstract

We report a massive intoxication by caffeine (20 g) with positive clinical evolution despite potentially lethal plasma concentrations (244 µg/mL) and delayed elimination.

Publication types

Case Reports
English Abstract
Letter

MeSH terms

Acidosis / chemically induced
Acute Kidney Injury / chemically induced
Adrenergic beta-Antagonists / therapeutic use
Caffeine / blood
Caffeine / pharmacokinetics
Caffeine / poisoning*
Cytochrome P-450 CYP1A2 / metabolism
Dose-Response Relationship, Drug
Electric Countershock
Humans
Hypokalemia / chemically induced
Male
Metabolic Clearance Rate
Propanolamines / therapeutic use
Rhabdomyolysis / chemically induced*
Suicide, Attempted
Theophylline / pharmacokinetics
Ventricular Fibrillation / chemically induced*
Ventricular Fibrillation / therapy
Young Adult

Substances

Adrenergic beta-Antagonists
Propanolamines
Caffeine
Theophylline
CYP1A2 protein, human
Cytochrome P-450 CYP1A2
esmolol
1,7-dimethylxanthine