Tissue plasminogen activator treatment of bilateral pulmonary emboli in a pediatric patient supported with a ventricular assist device

Justin Godown; Debra A Dodd; Thomas P Doyle; Andrew H Smith; Dana Janssen; Bret A Mettler

doi:10.1111/petr.12568

Tissue plasminogen activator treatment of bilateral pulmonary emboli in a pediatric patient supported with a ventricular assist device

Pediatr Transplant. 2015 Nov;19(7):E160-4. doi: 10.1111/petr.12568. Epub 2015 Jul 31.

Authors

Justin Godown¹, Debra A Dodd¹, Thomas P Doyle¹, Andrew H Smith^{1

2}, Dana Janssen¹, Bret A Mettler³

Affiliations

¹ Division of Pediatric Cardiology, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.
² Division of Pediatric Critical Care, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.
³ Division of Cardiac Surgery, Monroe Carell Jr. Children's Hospital at Vanderbilt, Nashville, TN, USA.

PMID: 26234922
DOI: 10.1111/petr.12568

Abstract

Bleeding and thrombosis are well-known potential complications of VAD support. We present a pediatric patient who developed massive bilateral pulmonary emboli while on BiVAD support that was successfully treated with intravenous tPA and bridged to heart transplant.

Keywords: pediatric heart transplant; pulmonary embolism; ventricular assist device.

Publication types

Case Reports

MeSH terms

Fibrinolytic Agents / therapeutic use*
Heart Failure / complications
Heart Failure / therapy*
Heart Transplantation
Heart-Assist Devices / adverse effects*
Humans
Infant
Male
Pulmonary Embolism / drug therapy*
Pulmonary Embolism / etiology
Tissue Plasminogen Activator / therapeutic use*

Substances

Fibrinolytic Agents
Tissue Plasminogen Activator