Repurposing of HDAC inhibitors toward anti-hepatitis C virus drug discovery: teaching an old dog new tricks

Fabao Zhao; Na Liu; Peng Zhan; Xinyong Liu

doi:10.4155/fmc.15.76

Repurposing of HDAC inhibitors toward anti-hepatitis C virus drug discovery: teaching an old dog new tricks

Future Med Chem. 2015;7(11):1367-71. doi: 10.4155/fmc.15.76.

Authors

Fabao Zhao¹, Na Liu¹, Peng Zhan¹, Xinyong Liu¹

Affiliation

¹ Department of Medicinal Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, Shandong, PR China.

PMID: 26230876
DOI: 10.4155/fmc.15.76

No abstract available

Keywords: cheminformatics; direct-acting antiviral drugs; drug repurposing; hepatitis C virus; histone deacetylase inhibitors; host cellular factors; hydroxamic acids.

Publication types

Editorial
Research Support, Non-U.S. Gov't

MeSH terms

Antiviral Agents / chemistry*
Antiviral Agents / pharmacology*
Drug Discovery / methods
Drug Repositioning* / methods
Hepacivirus / drug effects*
Hepatitis C / drug therapy*
Histone Deacetylase Inhibitors / chemistry*
Histone Deacetylase Inhibitors / pharmacology*
Humans
Hydroxamic Acids / chemistry
Hydroxamic Acids / pharmacology

Substances

Antiviral Agents
Histone Deacetylase Inhibitors
Hydroxamic Acids