Neutrophils, wounds, and cancer progression

Emily E Rosowski; Anna Huttenlocher

doi:10.1016/j.devcel.2015.07.005

Neutrophils, wounds, and cancer progression

Dev Cell. 2015 Jul 27;34(2):134-6. doi: 10.1016/j.devcel.2015.07.005.

Authors

Emily E Rosowski¹, Anna Huttenlocher²

Affiliations

¹ Departments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA.
² Departments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA. Electronic address: huttenlocher@wisc.edu.

PMID: 26218320
DOI: 10.1016/j.devcel.2015.07.005

Abstract

Chronic inflammation is associated with tumorigenesis, but how acute inflammation affects the tumor microenvironment is less known. Recently, Antonio et al. (2015) found that neutrophils attracted to an acute wound such as a biopsy drive cell proliferation of nearby pre-neoplastic cells, suggesting that acute wounds may promote cancer progression.

Publication types

Comment

MeSH terms

Animals
Humans
Melanoma / immunology*
Neoplasms, Experimental / immunology*
Precancerous Conditions / immunology*
Wounds and Injuries / immunology*
Zebrafish / immunology*