Persistent viral DNA detection in blood after primary herpes simplex 1 infection revealed by hepatitis with hemophagocytic syndrome

E K Alidjinou; A Dewilde; L Terriou; M Lazrek; I Engelmann; D Hober

doi:10.1016/j.jcv.2015.06.087

Persistent viral DNA detection in blood after primary herpes simplex 1 infection revealed by hepatitis with hemophagocytic syndrome

J Clin Virol. 2015 Aug:69:101-3. doi: 10.1016/j.jcv.2015.06.087. Epub 2015 Jun 19.

Authors

E K Alidjinou¹, A Dewilde¹, L Terriou², M Lazrek¹, I Engelmann¹, D Hober³

Affiliations

¹ Laboratoire de Virologie EA3610, Université Lille 2, Faculté de médecine, CHRU de, Lille, France.
² Service de Médecine Interne, Pôle de Médecine et Spécialités Médicales, CHRU de, Lille, France.
³ Laboratoire de Virologie EA3610, Université Lille 2, Faculté de médecine, CHRU de, Lille, France. Electronic address: didier.hober@chru-lille.fr.

PMID: 26209389
DOI: 10.1016/j.jcv.2015.06.087

Abstract

We here report the case of a 52-year old man who presented hepatitis with hemophagocytic syndrome triggered by herpes simplex 1 (HSV-1) primary infection. A high-level viremia was observed, and HSV-1 DNA remained detectable in blood for a long time after patient's recovery.

Publication types

Case Reports

MeSH terms

Acyclovir / therapeutic use
DNA, Viral / blood*
Etoposide / therapeutic use
Hepatitis, Viral, Human / blood
Hepatitis, Viral, Human / drug therapy
Hepatitis, Viral, Human / virology*
Herpes Simplex / blood
Herpes Simplex / complications
Herpes Simplex / drug therapy
Herpes Simplex / virology*
Herpesvirus 1, Human / drug effects
Herpesvirus 1, Human / genetics*
Humans
Immunoglobulins, Intravenous / therapeutic use
Lymphohistiocytosis, Hemophagocytic / blood
Lymphohistiocytosis, Hemophagocytic / drug therapy
Lymphohistiocytosis, Hemophagocytic / etiology*
Male
Middle Aged
Treatment Outcome
Viral Load / drug effects

Substances

DNA, Viral
Immunoglobulins, Intravenous
Etoposide
Acyclovir