Escaping Negative Selection: ILC You in the Gut

Immunity. 2015 Jul 21;43(1):12-4. doi: 10.1016/j.immuni.2015.07.006.

Abstract

How commensal-specific T cells are controlled in the periphery is poorly understood. In a recent issue of Science, Hepworth et al. (2015) show that ILC3s induce apoptosis of microbiota-specific CD4 T cells in a form of extrathymic negative selection.

Publication types

  • Comment

MeSH terms

  • Animals
  • Bacteria / immunology*
  • CD4-Positive T-Lymphocytes / immunology*
  • Colon / microbiology*
  • Female
  • Histocompatibility Antigens Class II / immunology*
  • Humans
  • Immunity, Innate*
  • Inflammatory Bowel Diseases / microbiology*
  • Male

Substances

  • Histocompatibility Antigens Class II