1 †Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.
2 ‡State Key Laboratory of Coordination Chemistry, Center for Multimolecular Organic Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China.
3 §Department of Chemistry, Colorado State University, Fort Collins, Colorado 80523, United States.
A highly enantioselective 6-exo-bromoaminocyclization of (E)-homoallylic N-tosylcarbamates catalyzed by a novel monophosphine-Sc(OTf)3 complex is described, giving a wide variety of optically active oxazinanones with high enantioselectivities.