Abstract
Residual immune activation was studied in 51 HIV-infected individuals, 16 with viral load between 1 and 20 copies/ml and 35 with viral load less than 1 copy/ml, and compared with results in 20 healthy blood donors. Higher T-cell activation and IP-10/CXCL10, MIG/CXCL9 and sCD14 plasma levels persisted in both HIV+ groups. The proportion of activated HLA-DR+ CD4 T cells was inversely correlated with the CD4 nadir and the current CD4 cell counts.
MeSH terms
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Adult
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Anti-Retroviral Agents / therapeutic use*
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Antiretroviral Therapy, Highly Active*
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Blood Donors
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CD4 Lymphocyte Count
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Chemokines / blood
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Cross-Sectional Studies
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Female
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HIV Infections / pathology*
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HIV-1 / immunology*
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HIV-1 / isolation & purification
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HLA-DR Antigens / analysis
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Humans
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Lipopolysaccharide Receptors / blood
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Lymphocyte Activation*
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Male
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Middle Aged
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Viral Load
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Viremia / drug therapy*
Substances
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Anti-Retroviral Agents
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Chemokines
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HLA-DR Antigens
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Lipopolysaccharide Receptors