Hybrid Crosslinked Methylcellulose Hydrogel: A Predictable and Tunable Platform for Local Drug Delivery

Malgosia M Pakulska; Katarina Vulic; Roger Y Tam; Molly S Shoichet

doi:10.1002/adma.201502767

Hybrid Crosslinked Methylcellulose Hydrogel: A Predictable and Tunable Platform for Local Drug Delivery

Adv Mater. 2015 Sep 9;27(34):5002-8. doi: 10.1002/adma.201502767. Epub 2015 Jul 16.

Authors

Malgosia M Pakulska^{1

2}, Katarina Vulic³, Roger Y Tam^{1

2}, Molly S Shoichet^{1

2

3}

Affiliations

¹ Department of Chemical Engineering and Applied Chemistry, University of Toronto, 200 College St., Toronto, ON, M5S 3E5, Canada.
² Institute for Biomaterials and Bioengineering, University of Toronto, 164 College St., Rm 407, Toronto, ON, M5S 3G9, Canada.
³ Department of Chemistry, University of Toronto, 80 St. George St., Toronto, ON, M5S 3H6, Canada.

PMID: 26184559
DOI: 10.1002/adma.201502767

Abstract

Design of experiment is used to develop a hybrid methylcellulose hydrogel that combines physical and chemical crosslinks, resulting in an injectable, in situ stiffening, and long-lasting material with predictable swelling and rheological properties. Chemical crosslinking is complete prior to injection, allowing for ease of use and storage. Controlled release of two relevant protein therapeutics and biocompatibility of the hydrogel are demonstrated.

Keywords: design of experiment; drug delivery; hydrogels; rheology; spinal cord injuries.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Drug Carriers / chemistry*
Drug Design
Drug Liberation
Hydrogels / chemistry*
Lactic Acid / chemistry
Methylcellulose / chemistry*
Nanoparticles / chemistry
Polyglycolic Acid / chemistry
Polylactic Acid-Polyglycolic Acid Copolymer

Substances

Drug Carriers
Hydrogels
Polylactic Acid-Polyglycolic Acid Copolymer
Polyglycolic Acid
Lactic Acid
Methylcellulose