Delineating cancer evolution with single-cell sequencing

Sci Transl Med. 2015 Jul 15;7(296):296fs29. doi: 10.1126/scitranslmed.aac8319.

Abstract

Single-cell sequencing methods are revolutionizing cancer research and medicine by providing powerful tools to investigate intratumor heterogeneity and rare subpopulations.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Breast Neoplasms / genetics*
  • Breast Neoplasms / pathology*
  • DNA Copy Number Variations
  • Disease Progression
  • Female
  • Gene Dosage
  • Genetic Heterogeneity
  • Genomics
  • High-Throughput Nucleotide Sequencing / methods*
  • Humans
  • Mutation
  • Phenotype
  • Sequence Analysis, DNA
  • Single-Cell Analysis*
  • Translational Research, Biomedical