Genetic Classification of Gliomas: Refining Histopathology

Michael B Foote; Nickolas Papadopoulos; Luis A Diaz Jr

doi:10.1016/j.ccell.2015.06.014

Genetic Classification of Gliomas: Refining Histopathology

Cancer Cell. 2015 Jul 13;28(1):9-11. doi: 10.1016/j.ccell.2015.06.014.

Authors

Michael B Foote¹, Nickolas Papadopoulos¹, Luis A Diaz Jr²

Affiliations

¹ The Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA; The Ludwig Center for Cancer Genetics and Therapeutic at Johns Hopkins, Baltimore, MD 21287, USA.
² The Swim Across America Laboratory at Johns Hopkins, Baltimore, MD 21287, USA; The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA; The Ludwig Center for Cancer Genetics and Therapeutic at Johns Hopkins, Baltimore, MD 21287, USA. Electronic address: ldiaz1@jhmi.edu.

PMID: 26175411
DOI: 10.1016/j.ccell.2015.06.014

Abstract

Newly published studies validate prior reports that specific combinations of genetic alternations in IDH1/2, ATRX, TERT, TP53, and co-deletion of 1p/19q have the ability to reclassify gliomas into rational subsets, defining a glioma's biological and clinical behavior more accurately than stratifications based solely on histopathology.

MeSH terms

Biomarkers, Tumor / genetics*
Brain Neoplasms / genetics
Brain Neoplasms / pathology*
Genomic Instability
Glioma / genetics
Glioma / pathology*
Humans
Prognosis

Substances

Biomarkers, Tumor