GEP-NETs UPDATE: Secreting gastro-enteropancreatic neuroendocrine tumours and biomarkers

Eur J Endocrinol. 2016 Jan;174(1):R1-7. doi: 10.1530/EJE-14-0971. Epub 2015 Jul 10.

Abstract

Neuroendocrine tumours (NETs) are rare tumours with an annual incidence in the population in a range of 2-5 new cases per 100,000 inhabitants. NETs are widely variable in terms of anatomical location, hormone production, clinical behaviour and syndromes they can cause. This article reviews the many localizations and clinical presentations of NETs with a main focus on clinical biomarkers and their use in medical practice.

Publication types

  • Review

MeSH terms

  • Biomarkers / blood*
  • Chromogranin A / blood
  • Humans
  • Immunohistochemistry
  • Intestinal Neoplasms / diagnosis*
  • Intestinal Neoplasms / metabolism*
  • Intestinal Neoplasms / therapy
  • Natriuretic Peptide, Brain / blood
  • Neuroendocrine Tumors / diagnosis*
  • Neuroendocrine Tumors / metabolism
  • Neuroendocrine Tumors / therapy
  • Organ Specificity
  • Pancreatic Neoplasms / diagnosis*
  • Pancreatic Neoplasms / metabolism*
  • Pancreatic Neoplasms / therapy
  • Pancreatic Polypeptide / blood
  • Peptide Fragments / blood
  • Prognosis
  • Recombinant Proteins / blood
  • Serotonin / blood
  • Stomach Neoplasms / diagnosis*
  • Stomach Neoplasms / metabolism*
  • Stomach Neoplasms / therapy

Substances

  • Biomarkers
  • Chromogranin A
  • Peptide Fragments
  • Recombinant Proteins
  • pro-brain natriuretic peptide (1-76)
  • pro-gastrin-releasing peptide (31-98)
  • Natriuretic Peptide, Brain
  • Serotonin
  • Pancreatic Polypeptide

Supplementary concepts

  • Gastro-enteropancreatic neuroendocrine tumor