HEXIM1 induction is mechanistically involved in mediating anti-AML activity of BET protein bromodomain antagonist

Leukemia. 2016 Feb;30(2):504-8. doi: 10.1038/leu.2015.142. Epub 2015 Jun 15.
No abstract available

Publication types

  • Letter
  • Research Support, N.I.H., Extramural

MeSH terms

  • Animals
  • Antineoplastic Agents / pharmacology*
  • Azepines / pharmacology
  • Cell Cycle Proteins
  • Humans
  • Leukemia, Myeloid, Acute / drug therapy*
  • Mice
  • Nuclear Proteins / antagonists & inhibitors*
  • RNA-Binding Proteins / physiology*
  • Transcription Factors / antagonists & inhibitors*
  • Triazoles / pharmacology
  • Xenograft Model Antitumor Assays

Substances

  • (+)-JQ1 compound
  • Antineoplastic Agents
  • Azepines
  • BRD4 protein, human
  • Cell Cycle Proteins
  • HEXIM1 protein, human
  • Nuclear Proteins
  • RNA-Binding Proteins
  • Transcription Factors
  • Triazoles