Characterization of nonmelanoma skin cancer for light therapy using spatial frequency domain imaging

Daniel J Rohrbach; Nathalie C Zeitouni; Daniel Muffoletto; Rolf Saager; Bruce J Tromberg; Ulas Sunar

doi:10.1364/BOE.6.001761

Characterization of nonmelanoma skin cancer for light therapy using spatial frequency domain imaging

Biomed Opt Express. 2015 Apr 20;6(5):1761-6. doi: 10.1364/BOE.6.001761. eCollection 2015 May 1.

Authors

Daniel J Rohrbach¹, Nathalie C Zeitouni², Daniel Muffoletto³, Rolf Saager⁴, Bruce J Tromberg⁴, Ulas Sunar⁵

Affiliations

¹ Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA.
² Department of Dermatology, University of Arizona Cancer Center, Tucson, AZ, USA.
³ Department of Electrical Engineering, University at Buffalo, Buffalo, NY, USA.
⁴ Beckman Laser Institute, University of California Irvine, Irvine, CA, USA.
⁵ Department of Cell Stress Biology, Roswell Park Cancer Institute, Buffalo, NY, USA ; Department of Biomedical Engineering, University at Buffalo, Buffalo, NY, USA.

Abstract

The dosimetry of light-based therapies critically depends on both optical and vascular parameters. We utilized spatial frequency domain imaging to quantify optical and vascular parameters, as well as estimated light penetration depth from 17 nonmelanoma skin cancer patients. Our data indicates that there exist substantial spatial variations in these parameters. Characterization of these parameters may inform understanding and optimization of the clinical response of light-based therapies.

Keywords: (110.4234) Multispectral and hyperspectral imaging; (170.0110) Imaging systems; (170.1870) Dermatology; (170.6935) Tissue characterization.

Abstract

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