Pheochromocytoma in a Pregnant Woman With Prior Traumatic Aortic Injury

Obstet Gynecol. 2015 Nov;126(5):1089-1094. doi: 10.1097/AOG.0000000000000909.

Abstract

Background: Pheochromocytoma, a catecholamine-producing tumor seldom encountered in pregnancy, is often heralded by nonspecific symptoms and undue mortality with delayed diagnosis. The presence of an aortic pseudoaneurysm poses a management challenge given the risk of aortic rupture amplified by hypertensive events.

Case: A 30-year-old woman, gravida 3 para 1, presented at 23 6/7 weeks of gestation with vomiting, chest pain, and severe hypertension. Investigation revealed adrenal pheochromocytoma and pseudoaneurysm at the site of a previous aortic injury. Prazosin and phenoxybenzamine achieved α-blockade with subsequent addition of labetalol for β-blockade. Concerns for aortic dissection led to endovascular aortic repair at 30 2/7 weeks of gestation. A female neonate was delivered by urgent cesarean delivery for persistent postprocedure fetal bradycardia. An adrenalectomy followed with near-immediate symptom resolution. Mother and neonate remain well.

Conclusion: The case underscores the necessity of a meticulous approach to hypertension management and the pivotal role of diligent multidisciplinary collaboration to achieve a safe outcome.

Publication types

  • Case Reports

MeSH terms

  • Adrenal Gland Neoplasms*
  • Adult
  • Aneurysm, False / surgery*
  • Aortic Aneurysm / surgery*
  • Female
  • Humans
  • Pheochromocytoma*
  • Pregnancy
  • Pregnancy Complications*