sFlt-1 and IP-10 in women with early-onset preeclampsia

Leandro De Oliveira; Niels Olsen S Câmara; José C Peraçoli; Maria T Peraçoli; Antonio F Moron; Nelson Sass

doi:10.1016/j.preghy.2011.02.002

sFlt-1 and IP-10 in women with early-onset preeclampsia

Pregnancy Hypertens. 2011 Apr;1(2):129-31. doi: 10.1016/j.preghy.2011.02.002. Epub 2011 Feb 23.

Authors

Leandro De Oliveira¹, Niels Olsen S Câmara², José C Peraçoli³, Maria T Peraçoli³, Antonio F Moron⁴, Nelson Sass⁵

Affiliations

¹ Obstetrics Department, Universidade Federal de São Paulo, Brazil; Laboratory of Immunobiology of Transplantation, Universidade de São Paulo, Brazil; Laboratory of Clinical and Experimental Investigation, Hospital e Maternidade Vila Nova Cachoeirinha, São Paulo, Brazil.
² Laboratory of Immunobiology of Transplantation, Universidade de São Paulo, Brazil.
³ Obstetrics Department, Universidade Estadual de São Paulo, Botucatu, Brazil.
⁴ Obstetrics Department, Universidade Federal de São Paulo, Brazil.
⁵ Obstetrics Department, Universidade Federal de São Paulo, Brazil; Laboratory of Clinical and Experimental Investigation, Hospital e Maternidade Vila Nova Cachoeirinha, São Paulo, Brazil.

PMID: 26104492
DOI: 10.1016/j.preghy.2011.02.002

Abstract

Intense inflammatory response and an anti-angiogenic state have been implicated in the pathogenesis of preeclampsia. Here, we investigated this hypothesis evaluating the serum concentrations of CXCL10/IP-10, sFlt-1, and PlGF in women with early-onset preeclampsia. CXCL10/IP-10 was measured by Cytometric Bead Array. sFlt-1 and PlGF were measured by automated electrochemiluminescence immunoassay. The median serum concentration of CXCL10/IP-10 was 109.5pg/mL in preeclamptic women, as compared with 52.28pg/mL in the controls (P=0.0028). The mean serum level of sFlt-1 was 13,636pg/mL in preeclamptic women, as compared with 2020pg/mL in the controls (P<0.0001). PlGF levels were significantly lower in women with preeclampsia.