Abstract
Nine new alkaloids of the koumine (1-4), humantenine (5-7), and yohimbane (8, 9) types as well as 12 known analogues were isolated from the leaves and vine stems of Gelsemium elegans. Compound 1 is the first N-4-demethyl alkaloid of the koumine type, compound 7 is the first nor-humantenine alkaloid, and compounds 8 and 9 are the first N-1-oxide and the first seco-E-ring alkaloids, respectively, of the yohimbane type. Compounds 1 and 7 exhibited moderate cytotoxicity against five human tumor cell lines with IC50 values in the range 4.6-9.3 μM.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkaloids / chemistry
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Alkaloids / isolation & purification
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Alkaloids / pharmacology
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Animals
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Antineoplastic Agents, Phytogenic / chemistry
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Antineoplastic Agents, Phytogenic / isolation & purification*
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Antineoplastic Agents, Phytogenic / pharmacology
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Cyclic N-Oxides / chemistry
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Cyclic N-Oxides / isolation & purification*
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Cyclic N-Oxides / pharmacology
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Drug Screening Assays, Antitumor
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Drugs, Chinese Herbal / chemistry
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Drugs, Chinese Herbal / isolation & purification*
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Drugs, Chinese Herbal / pharmacology
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Gelsemium / chemistry*
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Indole Alkaloids / chemistry
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Indole Alkaloids / isolation & purification
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Indole Alkaloids / pharmacology
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Inhibitory Concentration 50
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Lipopolysaccharides
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Macrophages / drug effects
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Mice
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Molecular Structure
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Nitric Oxide / biosynthesis
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Nuclear Magnetic Resonance, Biomolecular
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Plant Leaves / chemistry
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Plant Stems / chemistry
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Secologanin Tryptamine Alkaloids / chemistry
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Secologanin Tryptamine Alkaloids / isolation & purification*
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Secologanin Tryptamine Alkaloids / pharmacology
Substances
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Alkaloids
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Antineoplastic Agents, Phytogenic
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Cyclic N-Oxides
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Drugs, Chinese Herbal
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Indole Alkaloids
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Lipopolysaccharides
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Secologanin Tryptamine Alkaloids
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koumine
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yohimbane
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Nitric Oxide
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humantenine