Selenite-Releasing Bone Mineral Nanoparticles Retard Bone Tumor Growth and Improve Healthy Tissue Functions In Vivo

Adv Healthc Mater. 2015 Aug 26;4(12):1813-8. doi: 10.1002/adhm.201500307. Epub 2015 Jun 23.

Abstract

Selenite-doped bone mineral nanoparticles can retard the growth of osteosarcoma in a nude mice model, through sustained release of selenite ions. The selenite ions released from the nanoparticles through a degradation-mediated fashion inhibit tumor metastasis. Blood routine analysis indicates that selenite ions can also improve the functions of liver, kidney, and heart.

Keywords: bone minerals; hydroxyapatite; nanoparticles; osteosarcoma; selenite.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biocompatible Materials / chemistry
  • Biocompatible Materials / pharmacology
  • Bone Density / drug effects*
  • Bone Neoplasms / drug therapy*
  • Durapatite / chemistry
  • Durapatite / pharmacology
  • Mice
  • Mice, Nude
  • Nanoparticles / chemistry*
  • Selenious Acid / chemistry
  • Selenious Acid / pharmacology*

Substances

  • Biocompatible Materials
  • Durapatite
  • Selenious Acid