Controlled Synthesis of Ultrathin Lanthanide Oxide Nanosheets and Their Promising pH-Controlled Anticancer Drug Delivery

Chemistry. 2015 Aug 17;21(34):11954-60. doi: 10.1002/chem.201406470. Epub 2015 Jun 23.

Abstract

Various lanthanide oxides (Sm2 O3 and Gd2 O3 ) nanostructures were synthesized by a facile hydrothermal method. The loss of surfactants on the nanocrystals surface, followed by the resultant assembly is responsible for the formation of ultrathin nanosheets. Owing to strong surface effects, the different morphologies of the Sm2 O3 :5 % Eu and Gd2 O3 :5 % Eu nanocrystals present unique photoluminescence properties. As a proof-of-concept application, the as-obtained Sm2 O3 and Gd2 O3 ultrathin nanosheets exhibit promising pH-controlled anticancer drug-delivery behavior.

Keywords: drug delivery; gadolinium oxide; luminescence; nanostructures; samarium oxide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Drug Delivery Systems
  • Gadolinium / chemistry*
  • Gadolinium / metabolism
  • Hydrogen-Ion Concentration
  • Lanthanoid Series Elements / chemistry*
  • Luminescence
  • Nanoparticles / chemistry*
  • Nanostructures / chemistry*
  • Oxides / chemical synthesis*
  • Oxides / chemistry
  • Particle Size
  • Samarium / chemistry
  • Surface Properties

Substances

  • Antineoplastic Agents
  • Lanthanoid Series Elements
  • Oxides
  • Samarium
  • gadolinium oxide
  • samarium oxide
  • Gadolinium