Delivering a photosensitive transplatin prodrug to overcome cisplatin drug resistance

Chem Commun (Camb). 2015 Jul 21;51(57):11493-5. doi: 10.1039/c5cc03692e. Epub 2015 Jun 22.

Abstract

Clinically ineffective transplatin was converted into a photosensitive prodrug for drug delivery and triggered release to overcome cisplatin resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacokinetics
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Survival / drug effects
  • Cisplatin / administration & dosage*
  • Cisplatin / chemistry
  • Cisplatin / pharmacokinetics
  • Cisplatin / pharmacology*
  • Drug Resistance, Neoplasm
  • Humans
  • Neoplasms / drug therapy
  • Photochemical Processes
  • Prodrugs / administration & dosage*
  • Prodrugs / chemistry
  • Prodrugs / pharmacokinetics
  • Prodrugs / pharmacology*
  • Ultraviolet Rays

Substances

  • Antineoplastic Agents
  • Prodrugs
  • transplatin
  • Cisplatin