Enantioselective Hydroformylation of 1-Alkenes with Commercial Ph-BPE Ligand

Org Lett. 2015 Jul 2;17(13):3264-7. doi: 10.1021/acs.orglett.5b01421. Epub 2015 Jun 19.

Abstract

A rhodium complex, in conjunction with commercially available Ph-BPE ligand, catalyzes the branch-selective asymmetric hydroformylation of 1-alkenes and rapidly generates α-chiral aldehydes. A wide range of terminal olefins including 1-dodecene were examined, and all delivered high enantioselectivity (up to 98:2 er) as well as good branch:linear ratios (up to 15:1).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aldehydes / chemical synthesis*
  • Aldehydes / chemistry
  • Alkenes / chemistry*
  • Catalysis
  • Combinatorial Chemistry Techniques
  • Ligands
  • Molecular Structure
  • Rhodium / chemistry*
  • Stereoisomerism

Substances

  • Aldehydes
  • Alkenes
  • Ligands
  • Rhodium