Novel synthesis of carbocyclic nucleosides from 2-azabicyclo[2.2.1]heptanes via the reductive N2-C3 cleavage reaction as a key step

N Katagiri; M Muto; C Kaneko

Novel synthesis of carbocyclic nucleosides from 2-azabicyclo[2.2.1]heptanes via the reductive N2-C3 cleavage reaction as a key step

Nucleic Acids Symp Ser. 1989:(21):75-6.

Authors

N Katagiri¹, M Muto, C Kaneko

Affiliation

¹ Pharmaceutical Institute, Tohoku University, Sendai, Japan.

PMID: 2608486

Abstract

Carbocyclic ribofuranosyl and arabinofuranosyl pyrimidine nucleosides were synthesized stereoselectively from 2-azabicyclo[2.2.1]hept-5-en-3-one via NaBH4 promoted C-N bond cleavage reaction as a key step.

MeSH terms

Arabinonucleosides / chemical synthesis*
Lactams*
Nucleosides / chemical synthesis*

Substances

Arabinonucleosides
Lactams
Nucleosides
2-azabicyclo(2.2.1)hept-5-en-3-one