Second chances

Surv Ophthalmol. 2015 Nov-Dec;60(6):596-9. doi: 10.1016/j.survophthal.2015.06.002. Epub 2015 Jun 14.

Abstract

An 81-year-old woman presented with light perception vision in her left eye and had pallid swelling of the left optic disk. Temporal artery biopsy was normal. Magnetic resonance imaging revealed enlargement and enhancement of the left orbital optic nerve. There were vitreous cells, but a vitrectomy specimen showed only a benign lymphocytic population. Her vision deteriorated to no light perception in the left eye, and an optic nerve biopsy revealed a diffuse astrocytoma of World Health Organization grade II.

Keywords: IDH1 marker; TP53 marker; WHO grade II; optic nerve biopsy; optic nerve glioma/astrocytoma.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged, 80 and over
  • Astrocytoma / diagnosis*
  • Astrocytoma / metabolism
  • Biomarkers, Tumor / metabolism
  • Female
  • Humans
  • Hypertrophy
  • Isocitrate Dehydrogenase / metabolism
  • Magnetic Resonance Imaging
  • Optic Nerve / pathology
  • Optic Nerve Neoplasms / diagnosis*
  • Optic Nerve Neoplasms / metabolism
  • Papilledema / diagnosis
  • Tumor Suppressor Protein p53 / metabolism
  • Vision Disorders / diagnosis

Substances

  • Biomarkers, Tumor
  • TP53 protein, human
  • Tumor Suppressor Protein p53
  • Isocitrate Dehydrogenase
  • IDH1 protein, human