Abstract
We describe a novel peptide ligation/desulfurization strategy using a β-mercapto-N-glycosylated asparagine derivative. The newly developed procedure was successfully applied to the total chemical synthesis of the GM2 ganglioside activator protein bearing a monosaccharide on the native glycosylation site.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Chemistry Techniques, Synthetic
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Cysteine*
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G(M2) Activator Protein / chemical synthesis*
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G(M2) Activator Protein / chemistry*
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Glycosylation
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Models, Molecular
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Molecular Sequence Data
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Monosaccharides / chemistry
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Protein Conformation
Substances
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G(M2) Activator Protein
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Monosaccharides
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Cysteine