SnapShot: Kinase Inhibitors I

Jinhua Wang; Nathanael S Gray

doi:10.1016/j.molcel.2015.05.001

SnapShot: Kinase Inhibitors I

Mol Cell. 2015 May 21;58(4):708.e1. doi: 10.1016/j.molcel.2015.05.001.

Authors

Jinhua Wang¹, Nathanael S Gray¹

Affiliation

¹ Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA 02215, USA; Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA.

PMID: 26000854
DOI: 10.1016/j.molcel.2015.05.001

Abstract

Selective small-molecule inhibitors of protein kinases can serve as powerful tools to elucidate biological function. Efforts to develop potential drug candidates have yielded a wealth of kinase inhibitors. However, selecting the optimal kinase inhibitor for a particular application can be challenging. While the optimal inhibitor will be application specific, we have attempted to summarize some of the best reported inhibitors for various kinases.

MeSH terms

Animals
Biocatalysis / drug effects
Humans
Phosphorylation / drug effects
Protein Kinase Inhibitors / pharmacology*
Protein Kinases / metabolism*
Signal Transduction / drug effects*
Small Molecule Libraries / pharmacology*

Substances

Protein Kinase Inhibitors
Small Molecule Libraries
Protein Kinases