Deciphering the tubulin code

Stefan Raunser; Christos Gatsogiannis

doi:10.1016/j.cell.2015.05.004

Deciphering the tubulin code

Cell. 2015 May 21;161(5):960-961. doi: 10.1016/j.cell.2015.05.004.

Authors

Stefan Raunser¹, Christos Gatsogiannis²

Affiliations

¹ Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany. Electronic address: stefan.raunser@mpi-dortmund.mpg.de.
² Department of Structural Biochemistry, Max Planck Institute of Molecular Physiology, 44227 Dortmund, Germany.

PMID: 26000474
DOI: 10.1016/j.cell.2015.05.004

Abstract

Enzymes of the tubulin tyrosine ligase-like (TTLL) family posttranslationally modify and thereby mark microtubules by glutamylation, generating specific recognition sites for microtubule-interacting proteins. Garnham et al. report the first structure of a TTLL protein alone and in complex with microtubules, elucidating their mechanism of action.

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MeSH terms

Animals
Humans
Peptide Synthases / chemistry*
Peptide Synthases / metabolism*

Substances

Peptide Synthases