Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease

Amedeo Amedei; Nicola Pimpinelli; Alessia Grassi; Chiara Della Bella; Elena Niccolai; Simona Brancati; Marisa Benagiano; Sofia D'Elios; Alberto Bosi; Mario M D'Elios

doi:10.1007/s13317-013-0054-7

Skin CD30(+) T cells and circulating levels of soluble CD30 are increased in patients with graft versus host disease

Auto Immun Highlights. 2013 Aug 31;5(1):21-6. doi: 10.1007/s13317-013-0054-7. eCollection 2014 Jun.

Affiliations

¹ Dipartimento di Medicina Sperimentale e Clinica, Università di Firenze, Largo Brambilla 3, 50134 Florence, Italy.
² Dipartimento di Chirurgia e Medicina Traslazionale, Università di Firenze, Florence, Italy.

Abstract

Objective: To determine serum soluble CD30 (sCD30) levels in patients with graft versus host disease (GVHD).

Methods: Serum soluble CD30 levels and IgE levels were assayed by a sensitive ELISA in 57 patients with bone marrow transplantation, and in 44 healthy controls. We analyzed the type of effector T cells in patients with GVHD.

Results: Serum levels of sCD30 and serum IgE levels were significantly higher (p values <0.05) in patients with acute and chronic GVHD than in healthy controls. We found that CD30(+) T-cells are present in the skin of patients with GVHD.

Conclusion: These results suggest that serum sCD30 levels may be helpful for the management of patients with bone marrow transplantation.

Keywords: Autoimmunity; CD30; Cytokines; Graft versus host disease; Systemic sclerosis.