Case Study: Diffuse Large B-Cell Lymphoma Arising in Ovarian Mature Cystic Teratoma

Int J Gynecol Pathol. 2015 Sep;34(5):459-64. doi: 10.1097/PGP.0000000000000172.

Abstract

We describe an unexpected finding of diffuse large B-cell lymphoma associated with mature cystic teratoma of the ovary. A 68-yr-old woman with a complex left ovarian cystic mass on imaging underwent bilateral salpingo-oophorectomy, lymphadenectomy, appendicectomy, and omentectomy. Histopathologic examination revealed nodules of malignant non-Hodgkin lymphoma within the teratoma. A diagnosis of diffuse large B-cell lymphoma, germinal center cell subtype by Hans criteria was made after immunostaining and molecular studies. The patient was treated with R-CHOP chemotherapy and remains disease-free at 14-mo follow-up.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Monoclonal, Murine-Derived
  • Antineoplastic Combined Chemotherapy Protocols
  • Appendectomy
  • Cyclophosphamide
  • Doxorubicin
  • Female
  • Gene Rearrangement
  • Humans
  • Immunoglobulins / genetics
  • Immunohistochemistry
  • Lymph Node Excision
  • Lymphoma, Large B-Cell, Diffuse / drug therapy
  • Lymphoma, Large B-Cell, Diffuse / pathology*
  • Lymphoma, Large B-Cell, Diffuse / surgery
  • Neoplasms, Second Primary / drug therapy
  • Neoplasms, Second Primary / pathology
  • Neoplasms, Second Primary / surgery
  • Omentum / surgery
  • Ovarian Neoplasms / drug therapy
  • Ovarian Neoplasms / pathology*
  • Ovarian Neoplasms / surgery
  • Ovariectomy
  • Prednisone
  • Rituximab
  • Salpingectomy
  • Teratoma / drug therapy
  • Teratoma / pathology*
  • Teratoma / surgery
  • Vincristine

Substances

  • Antibodies, Monoclonal, Murine-Derived
  • Immunoglobulins
  • R-CHOP protocol
  • Rituximab
  • Vincristine
  • Doxorubicin
  • Cyclophosphamide
  • Prednisone

Supplementary concepts

  • Teratoma, Ovarian