Partial protein domains: evolutionary insights and bioinformatics challenges

Genome Biol. 2015 May 19;16(1):100. doi: 10.1186/s13059-015-0663-8.

Abstract

Protein domains are generally thought to correspond to units of evolution. New research raises questions about how such domains are defined with bioinformatics tools and sheds light on how evolution has enabled partial domains to be viable.

Publication types

  • Research Support, Non-U.S. Gov't
  • Comment

MeSH terms

  • Animals
  • Bacterial Proteins / genetics*
  • Gene Deletion*
  • Genes, Bacterial*
  • Humans
  • Luciferases / genetics*
  • Molecular Sequence Annotation*
  • Oxidoreductases / genetics*
  • Protein Structure, Tertiary*
  • Proteins / chemistry*
  • Sequence Alignment*

Substances

  • Bacterial Proteins
  • Proteins
  • Oxidoreductases
  • luxG protein, Bacteria
  • Luciferases