Abstract
We investigated the impact of oxygenation status (measured by EPR oximetry) on the uptake of (18)F-FDG (measured by PET) in two different tumor models during a carbogen breathing challenge. We observed a significant drop in (18)F-FDG uptake under carbogen breathing that suggests a rapid metabolic adaptation to the oxygen environment.
Keywords:
(18)F-FDG-PET; Carbogen; EPR; Tumor oxygenation.
Copyright © 2015 Elsevier Ireland Ltd. All rights reserved.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Carbon Dioxide / administration & dosage
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Carbon Dioxide / metabolism*
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Disease Models, Animal
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Electron Spin Resonance Spectroscopy
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Female
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Fluorodeoxyglucose F18 / pharmacokinetics*
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Hypoxia / metabolism*
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Mice
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Mice, Nude
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Neoplasms, Experimental / diagnostic imaging
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Neoplasms, Experimental / metabolism
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Oximetry
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Oxygen / administration & dosage
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Oxygen / metabolism*
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Positron-Emission Tomography
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Radiopharmaceuticals / pharmacokinetics*
Substances
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Radiopharmaceuticals
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Fluorodeoxyglucose F18
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Carbon Dioxide
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carbogen
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Oxygen