The increase in tumor oxygenation under carbogen breathing induces a decrease in the uptake of [(18)F]-fluoro-deoxy-glucose

Radiother Oncol. 2015 Sep;116(3):400-3. doi: 10.1016/j.radonc.2015.04.023. Epub 2015 May 14.

Abstract

We investigated the impact of oxygenation status (measured by EPR oximetry) on the uptake of (18)F-FDG (measured by PET) in two different tumor models during a carbogen breathing challenge. We observed a significant drop in (18)F-FDG uptake under carbogen breathing that suggests a rapid metabolic adaptation to the oxygen environment.

Keywords: (18)F-FDG-PET; Carbogen; EPR; Tumor oxygenation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Carbon Dioxide / administration & dosage
  • Carbon Dioxide / metabolism*
  • Disease Models, Animal
  • Electron Spin Resonance Spectroscopy
  • Female
  • Fluorodeoxyglucose F18 / pharmacokinetics*
  • Hypoxia / metabolism*
  • Mice
  • Mice, Nude
  • Neoplasms, Experimental / diagnostic imaging
  • Neoplasms, Experimental / metabolism
  • Oximetry
  • Oxygen / administration & dosage
  • Oxygen / metabolism*
  • Positron-Emission Tomography
  • Radiopharmaceuticals / pharmacokinetics*

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18
  • Carbon Dioxide
  • carbogen
  • Oxygen